| Title: | Thin-layer hydroxyapatite deposition on a nanofiber surface stimulates mesenchymal stem cell proliferation and their differentiation into osteoblasts |
| Authors: | Prosecká, Eva Buzgo, Matej Rampichová, Michala Kocourek, Tomáš Kochová, Petra Vysloužilová, Lucie Tvrdík, Daniel Jelínek, Miroslav |
| Citation: | Journal of Biomedicine and Biotechnology. 2012, article id: 428503. |
| Issue Date: | 2012 |
| Publisher: | Hindawi Publishing |
| Document type: | článek article |
| URI: | http://www.hindawi.com/journals/bmri/2012/428503/ http://hdl.handle.net/11025/1754 |
| ISSN: | 1110-7243 |
| Keywords: | tenké vrstvy;pulzní laserová depozice;nanovlákna |
| Keywords in different language: | nanofibres;thin layers;pulse laser deposition |
| Abstract: | Pulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-ε-caprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with thin layers of HA (200nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young’s moduli of elasticity significantly increased. Clearly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm. |
| Rights: | © 2012 Eva Prosecká et al. |
| Appears in Collections: | Články / Articles (NTIS) OpenAire |
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