Title:	Titanium-based porous materials with nanostructured bioactive surface for enhanced osseointegration
Authors:	Křenek, Tomáš Kovařík, Tomáš Docheva, Denitsa Stich, Theresia Kadlec, Jaroslav
Citation:	JIRKOVÁ, Hana ed.; JENÍČEK, Štepán ed. Proceedings PING 2019: modern trends in material engineering: 10.-13.09.2019, Pilsen. 1. vyd. Plzeň: University of West Bohemia, 2019, s. 110. ISBN 978-80-261-0879-5.
Issue Date:	2019
Publisher:	University of West Bohemia
Document type:	konferenční příspěvek conferenceObject
URI:	http://hdl.handle.net/11025/35271
ISBN:	978-80-261-0879-5
Keywords:	biomateriály;titan;pórovitost;nanostrukturovaný povrch;chemická aktivace;životaschopnost buněk
Keywords in different language:	biomaterials;titanium;porosity;nanostructured surface;chemical activation;cell viability
Abstract in different language:	Despite the great progress that has been achieved in orthopedics biomaterials, fixation of implants to the bone host remains a problem. Mismatch of Young’s moduli of the biomaterials and the surrounding bone has been identified as a major reason for implant loosening following stress shielding of bone. However, the implanted material must be strong enough and durable to withstand the physiological loads placed upon it over the years. A suitable balance between strength and stiffness has to be found to the best match of bone behaviour. Titanium and its alloy (Ti6Al4V) have elastic moduli less than 50% of that commonly used Co–Cr implants so that their use helps reduce the extent of stress shielding. One consideration to achieve this has been the development of materials that exhibit substantial surface or total bulk porosity in medical applications. Moreover, bioactive surface chemical composition and suitable surface morphology on micro- and nanoscale level is necessary for efficient osseointegration. Here we report on novel concept of hierarchically functionalized titanium based biomaterials consists in (i) laser induced surface porosity, (ii) micro/messoporous bioactive glass fillers, (iii) chemical activation and/or ablative deposition of bioactive CaTiO3 nanoparticles. Prepared biomaterials were analyzed using SEM/EDX, XRD, Raman spectroscopy and test in terms of cell cultivation in order to reveal biocompatibility, cell viability and osseointegration ability.
Rights:	© University of West Bohemia
Appears in Collections:	Proceedings PING 2019: modern trends in material engineering Konferenční příspěvky / Conference Papers (CTM) Proceedings PING 2019: modern trends in material engineering

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.